Conventional Vicky, who is engaged to Doug, travels to Barcelona to spend her summer holidays at the home of their parent's friends, Judy and Mark Nash, with her unconventional and open-minded friend, Cristina. While in a restaurant, the divorced painter Juan Antonio Gonzalo flirts and invites them to travel to Oviedo with him, and also to go to bed with him. The reluctant Vicky does not accept the invitation but Cristina agrees. Once in Oviedo, Cristina develops an ulcer so Vicky goes sightseeing alone with Juan Antonio. Vicky eventually falls in love with Juan Antonio and has sex with him. However, back in Barcelona, she does not say anything to her friend and Cristina moves into Juan Antonio's house, while Vicky marries Doug. When the unstable former wife of Juan Antonio, Maria Elena, overdoses, the painter brings her to his house and their troubled relationship harmonizes with the presence of Cristina.

Idealistic lawyers Mike Weiss and Paul Danziger are partners. Mike is a drug-addict and and Paul is a family man with a pregnant wife. When nurse Vicky Rogers seeks them out, they learn that she has contracted AIDS a couple of years ago when she was accidentally pinpricked with a contaminated needle by a violent patient. Vicky shows a retractable safety needle invented by engineer Jeffrey Matthew Dancort, who owns the Safety Point Company, but is unable to sell his product to any hospital from the United Medical group, apart from San Antonio Memorial. Danziger and Weiss accept the case and go to court against United Medical, defended by powerful lawyer Nathaniel Price. Soon, they see all the doors closed in their fight against the powerful mafia of the medical supply system.

Martinez's interrogation of Michael reveals the identity of the traitor within the President's team. Meanwhile, Sean is wounded and Leila abducts a doctor to treat him, and Dempsey gives Vicky a new mission.

The CDC works to identify the biological agent and treat the infected persons while the White House and Sterling negotiate with Thomas. In other events, Simon wants Sophia to turn on Thomas and Collier comes closer to catching Vicky and Carter.